Gastrointestinal stromal tumour (GIST) is the most common mesenchymal neoplasm of the Gastrointestinal (GI) tract. Forty-nine years old man with no medical history was presented to the emergency service with abdominal pain, he underwent laparoscopic exploration with pre-diagnosed acute appendicitis. Ileal GIST was detected localized in the right - lower quadrant at the operation and resected by laparoscopically. Patients with GIST may be presented with various clinical symptoms including acute abdomen, Laparoscopic exploration allows the diagnosis and treatment at the same operation and laparoscopic surgery is a safe and reasonable option in small bowel GIST's.
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