In vitro antidiabetic activity of Caesalpina digyna (R.) methanol root extract

Diabetes is a clinical syndrome characterized by hyperglycemia due to absolute or relative deficiency of insulin. Recent decades have experienced a sharp increase in the incidence and prevalence of diabetes mellitus. One antidiabetic therapeutic approach is to reduce gastrointestinal glucose production and absorption through the inhibition of carbohydrate digesting enzymes such as α- amylase and α-glucosidase and α-amylase. Inhibition of amylase and glucosidase enzymes involved in digestion of carbohydrates can significantly decrease the post prandial increase of blood glucose after a mixed carbohydrate diet and therefore can be an important strategy in management of blood glucose. The aim of the current study was to screen the methanol extract of root of Caesalpinia digyna for its in vitro antidiabetic activity. Our assay result suggests that methanol extract of Caesalpinia digyna exhibit dose-dependent increase in percentage inhibitory activity on α-glucosidase enzymes (IC50 402.23±10.14 μg/ml) and α- amylase (IC5 of 686.94 ± 3.98 μg/ml). Acarbose was used as a standard drug.

Author(s): M. B. Narkhede*, P. V. Ajimire, A. E. Wagh, Manoj Mohan and A.T. Shivashanmugam

Abstract | PDF

Share This Article