Hematological studies on the effect of Sacharrum barberi extract on guinea pigs and albino wistar rats

The results of the hematological indices examined in the experimental animals Albino wistar rats and Guinea pigs were investigated respectively. Forty Albino wistar rats and Guinea pigs of male sex were randomly assigned into four study groups of ten animals each to give in all four study groups of male wistar rats and Guinea pigs respectively. Graded doses of the alcoholic extracts 100mg/kg, 200mg/kg and 300mg/kg body weight in normal saline were administered to the treatment groups II, III and IV via orogastric tube; the control group I received placebo (normal saline) for 21 days. At the end of 21days period, the experiments were terminated. Hematological finding gathered unsteady rise in RBC, WBC, PCV and MCHC value for Albino wistar rats and Guinea pigs but no steady reduction was noticed for the Hb and platelet indices. In general, the values that were obtained either at an increasing level or decreasing level still falls within the normal range of these hematological parameters for the Albino wistar rats and Guinea pigs and hence it is not a significance change at p<0.05.

Author(s): Ukpanukpong RU, Ejoba R, Uyabeme RN, Ajakaye OF, Oresegun OA, Eze FN, Fana NY and Edoamodu CE

Abstract | PDF

Share This Article