Evaluation of antidiarrhoeal effect of Black pepper (Piper nigrum L.)

Aqueous black pepper extract (75, 150, 300 mg/kg, po) was tested for its antidiarrhoeal, antimotility and antisecretory activity in mice. The methods of castor oil and magnesium sulphate induced diarrhoea were used to evaluate antidiarrhoeal activity, while charcoal meal test and castor oil induced intestinal secretions were used for testing antimotility and antisecretory activity in mice. Aqueous Black pepper extract (ABPE) produced a significant and dose dependent antidiarrhoeal, antimotility, and antisecretory effect. Preliminary phytochemical screening of ABPE showed the presence of carbohydrates, and alkaloids. It can be concluded that ABPE possesses antidiarrhoeal effect may be due to its antimotility and antisecretory effect. Antimotility and antisecretory effect of Black pepper may be due to the presence of carbohydrates and alkaloids.

Author(s): Prashant B. Shamkuwar*, Sadhana R. Shahi and Suvarna T. Jadhav

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