Effect of Black pepper on antidiarrhoeal activity of an Ayurvedic formulation: Kutajarishta

Aqueous Black pepper extract, Kutajarishta and Kutajarishta along with aqueous Black pepper extract were tested for antidiarrhoeal, antimotility and antisecretory activity in mice. The methods of castor oil and magnesium sulphate induced diarrhoea were used to evaluate antidiarrhoeal activity, while charcoal meal test and castor oil induced intestinal secretions were used for testing antimotility and antisecretory activity in mice. Aqueous Black pepper extract (ABPE) produced a significant increase in the antidiarrhoeal, antimotility, and antisecretory effect of Kutajarishta. It can be concluded that ABPE produces additive effect with Kutajarishta in treating diarrhoea by enhancing its antimotility, and antisecretory activity.

Author(s): Prashant B. Shamkuwar* and Sadhana R. Shahi

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