Journal of Clinical Medicine and Therapeutics

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Familial Mediterranean Fever

Familial Mediterranean fever (FMF) is a hereditary inflammatory disorder. FMF is an auto inflammatory disease caused by mutations in Mediterranean fever gene, which encodes a 781–amino acid protein called pyrin. While all ethnic groups are susceptible to FMF, it generally occurs more in people of Mediterranean origin—including Sephardic Jews, Mizrahi Jews, Ashkenazi Jews, Armenians, Azerbaijanis, Arabs, Kurds, Greeks, Turks and Italians. The disorder has been assigned various names such as familial paroxysmal polyserositis, periodic peritonitis, recurrent polyserositis, benign paroxysmal peritonitis, periodic disease or periodic fever, Reimann periodic disease or Reimann syndrome, Siegal-Cattan-Mamou disease, and Wolff periodic disease.

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