Dr. Shhyam Moorthy
The University of Texas M.D. Anderson Cancer Center, USA.
Doctor of Philosophy, Ph.D. | 2010-2015 | University of Texas Graduate School of Biomedical Sciences and M.D. Anderson Cancer Center, Houston, TX.
Bachelor of Science (Honors), B.S. | 2006-2010 | Louisiana State University, Baton Rouge, LA.
Basic Science Expertise:- NOTCH signaling, Head and Neck Cancers, AXL signaling pathway, signal transduction, transcription and translation, targeted therapy, oncogenes and tumor suppressors, pre-clinical mice models. Clinical Expertise:- Phase 1 clinical trial design, BOIN and modified-Fibonacci dose escalation, immunotherapy, targeted therapy, drug-related toxicities, RECIST evaluation for tumor progression.Technique expertise: Mammalian Tissue Culture, RNA extraction, molecular cloning, western blots, immunohistochemistry, in vivo orthotopic tumor models, flow cytometry, retroviral and lentiviral transductions, transfections, drug-dose study, stable knock down, overexpression studies, transient electroporation, competitive cell proliferation assays, senescence, CRISPR-Cas9 knockouts, clonogenic assays, live-cell imaging, transwell invasion/migration assays and qRT-PCR.