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PCOS 2018 Journal of Clinical and Molecular Endocrinology
ISSN: 2572-5432 Page 31
June 07-08, 2018
London, UK
4th World Congress on
Polycystic Ovarian
Syndrome
Introduction: Adiponectin is produced and expressed by adipose
tissue, which is prevalent in Polycystic Ovarian Syndrome with
increased Body Mass Index (BMI), Adiponectin has profound
insulin – sensitizing, anti-inflammatory and anti-atherogenic
effects.
Objective of the study is to investigate the association between
weight reduction inobese adolescentswithPCOSandadiponectin
and TNF-α and C-R-P.
Patients and Methods: Twenty-seven adolescent women
between 10 and 20 years with anovulation and hyperandrogenism
were recruited from the outpatient clinic over a three year period
September 1, 2014 to August 31, 2017. All had clinical evaluation
including history and physical examination – weight and height
and Body Mass Index. They were randomized into 3 treatment
groups: Metformin only, Metformin and Exercise and Exercise
only. Serum levels of adinopectin, TNF-α, and C-reactive protein
were estimated by ELISA technique initially before treatment and
repeated after 3 months of treatment.
Results: The features of oligomenorrhoae, high BMI and acne like
in other parts of the world. All the three interventions resulted in
weight reduction and regular menstruation in about 34% of the
young women. Metformin with exercise had more significant
effect in decreasing total 50% as compared to 28% with
metformin only and 14% with exercise only. Similarly, Metformin
with exercise had amore significant increase of adiponectin (3.42
Vs 8.48 P < 0.001) decrease of TNF-α (11.08 Vs 48.4 P <0.020)
and C-RP (20.8 Vs 11.4 P<0.031).
Conclusion: Weight reduction in Obese adolescents with PCOS
is associated with increased level of adiponectin and decrease
levels of TNF-α and C-Reactive Protein.
Keywords:Adolescent, Adiponectin, weight reduction, Metformin,
Tumor Necrosis Factor Alpha.
Biography
Dr Alexander E. Omu is a Professor in Department of Obstetrics and Gyne-
cology and Faculty of Medicine at Health Sciences’ Center (HSC), Kuwait
University, Kuwait.
The weight reduction in adolescents with Polycystic Ovarian
Syndrome is associated with increase in serum adinopectin
Omu AE1,2, Al-Saeed B 2, Behbehani A2 and A-Azemi MK1,2
Department of Obstetrics and Gynecology, Faculty of Medicine
Kuwait University and Maternity Hospital, Kuwait
Omu AE et al., J Clin Mol Endocrinol 2018, Volume 3
DOI: 10.21767/2572-5432-C1-003