pcos-2018-posters-accepted-abstracts

2 / 25

PCOS 2018 Journal of Clinical and Molecular Endocrinology
ISSN: 2572-5432 Page 30
June 07-08, 2018
London, UK
4th World Congress on
Polycystic Ovarian
Syndrome
Objective: PCOS affects approximately 4–12% women of
reproductive age. For such a common syndrome, there is
surprisingly a lack of well-defined diagnostic criteria, making it
confusing to doctors. Furthermore, the symptoms of PCOS range
from physical to psychological and can also lead to infertility. It
was thus, pertinent to deliberate upon more ways of managing
PCOS and so the objective of the study was to find out the effect
of standardized fenugreek seed extract on reduction in ovarian
volume and the number of ovarian cysts.
Method: An open-label, single armed, single-centric and non-
comparative study on 107 female patients suffering from PCOS
was conducted using a novel fenugreek seed extract for a period
of 12 weeks to determine its efficacy in reduction of ovary volume
and number of ovarian cysts. The inclusion criteria for the study
were premenopausal women between 18–45 years of age and
BMI less than 42, diagnosed with PCOS by Rotterdam Criteria
with adequate hepatic, renal, cardiac, hematological functions
and with a stable weight for the last two months (i.e. change
of weight <3kgs). Patients willing to participate submitted an
informed consent in writing for the study. Data was described
as mean ± standard deviation. The baseline characteristics
were compared between the two groups using t-test and other
statistical parameters.
Results: On completion of the study, significant decrease was
noticed in both the ovaries’ volume (p-value 0.0001). More
than 65% of the patients showed reduction in cyst size in both
left and right ovaries. 15 patients got pregnant by the end of
the study and HOMA Index was reduced in 75.67% of the study
population. 79.5% of the study population had regular menstrual
cycles at the completion of the study and prolactin levels were
significantly reduced. Hirsutism score was significantly reduced
(p=0.002) at the end of 12 weeks of treatment. No changes were
observed in liver function test (LFT), kidney function test (KFT)
and haemogram levels.
Conclusions: The fenugreek seeds extract was proven to be safe
and effective in treating PCOS in women of reproductive age by
reducing the cyst volume in both ovaries as well as cyst sizes.
Biography
Apurva Goel has completed her Masters in Law and started her professional
career in healthcare segment. She is currently working at a Senior Position
in Chemical Resources (CHERESO), India. In addition to her background in
leadership, she has in-depth understanding of natural products, life scienc-
es, research protocols, business development, product development, and
market research. She is a young self-made disciplinarian, who has crossed
the boundaries of success with her sincere dedication and a crystal clear
vision to provide effective healthcare.
Clinical evaluation of furostanolic saponins and flavonoids in
polycystic ovarian syndrome (PCOS) patients
Apurva Goel1, Pushplata Sankhwar2, S P Jaiswar2 and Kiran Tiwari1
1Chemical Resources (CHERESO), India
2King George’s Medical University, India
Apurva Goel et al., J Clin Mol Endocrinol 2018, Volume 3
DOI: 10.21767/2572-5432-C1-003