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PCOS 2018
Journal of Clinical and Molecular Endocrinology
ISSN: 2572-5432
Page 37
June 07-08, 2018
London, UK
4
th
World Congress on
Polycystic Ovarian
Syndrome
T
he polycystic ovary syndrome (PCOS) accounts for
approximately 80% of women with anovulatory infertility.
Various factors influencing ovarian function and fertility are
adversely affected by an individual being overweight, the degree
of hyperandrogenism and having elevated serum concentrations
of luteinizing hormone (LH). Interestingly, a Finnish study showed
that whilst women with PCOS may take longer to conceive,
but their lifetime fertility is not impaired and they may display
sustained fertility with advancing age as compared with infertile
eumenorrheic women. For those who do present with anovulatory
infertility,theprinciplesoftherapyarefirsttooptimizehealthbefore
commencing treatment and then induce regular unifollicular
ovulation, whilst minimizing the risks of ovarian hyperstimulation
syndrome (OHSS) andmultiple pregnancies. Weight loss, in those
who are overweight, should improve the endocrine profile, the
likelihood of ovulation, a healthy pregnancy and the response to
ovulation induction therapy. Anovulation associated with PCOS
has long been known to be amenable to surgical treatment, and
a long-term cohort study has shown persistence of ovulation and
normalization of serum androgens and sex hormone-binding
globulin (SHBG) up to 20 years after laparoscopic ovarian
electrocautery in over 60% of subjects, particularly if they have a
normal BMI. There is interesting new data on improved efficacy
using aromatase inhibitors compared with clomiphene citrate
(CC).
In vitro
fertilization (IVF) may be required for women with
anovulatory PCOS who do not conceive with ovulation induction
or if there are other fertility factors such as tubal damage or
male factors. The effect of basal serum LH and LH/FSH ratio on
outcomes of
in vitro
fertilization-embryo transfer in patients with
polycystic ovarian syndrome will be discussed.
faraj68@hotmail.comPolycystic ovary syndrome and anovulatory infertility: An
evolving strategy
Radwa Faraj
The Rotherham NHS Foundation Trust–South Yorkshire, UK
J Clin Mol Endocrinol 2018, Volume 3
DOI: 10.21767/2572-5432-C1-003