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Page 71
Volume 4, Issue 2 American Journal of Ethnomedicine
ISSN 2348-9502
Natural Products Congress & World Pharma Congress 2017
October 16-18, 2017
3rd World Congress on
NATURAL PRODUCTS CHEMISTRY AND RESEARCH
&
12th WORLD PHARMA CONGRESS
October 16-18, 2017 Budapest, Hungary
Effect of ethyl acetate leaf fraction of Gongronema Latifolium on alloxan induced diabetes rats
Effiong1, Grace Sylvester and Ekpe Ini Patrick2
1University of Uyo, Nigeria
2The Catholic University of Nigeria, Nigeria
Diabetes mellitus is a metabolic disorder caused by insufficient or absent production of the hormone insulin by the
pancreas. The effect of ethyl acetate fraction of Gongronema latifolium on body weight, blood glucose level and lipid
profile was evaluated in alloxan-induced diabetic rats using standard methods. The result revealed that there is a significant
increase in body weight of Groups 2(15.17%), Group 3(12.05%) and group 4(14.05%) after 14 days treatment when compared
with untreated diabetic rats (-5.61%). The effect of treatments on blood glucose level of alloxan-induced diabetic rats shows
a significant increase (P<0.05) of percentage change of blood glucose in group 2(43.05%), 3(23.50%) and 4(43.36%) when
compared with group 1(8.87%) and also a significant increase (P<0.05) in groups 2 and 4 when compared to group3 on the
14th day of treatment. The results of the determined serum lipid profile indicates a significant decrease (P<0.05) in the levels
of serum TC, TG, LDL-C and VLDL-C and a significant increase (P<0.05) in the level of serum HDL-C of group 2(TC=3.01
± 0.12mg/dl, TG=2.31 ±0.14mg/dl, LDL-C=0.83 ± 0.28mg/dl, VLDL-C=0.46 ± 0.34mg/dl and HDL-C=1.72 ± 0.29mg/dl),
Group 3(TC=4.56 ± 0.96mg/dl, TG=2.52 ± 0.24mg/dl, LDL-C, 1.13 ± 0.09mg/dl VLDL-C=0.95 ± 0.16mg/dl and HDL-C=1.27
± 0.10mg/dl) and Group 4(TC=3.56 ± 0.64mg/dl, TG=2.36 ± 0.16, LDL-C=0.09 ± 0.14mg/dl, VLDL-C=0.67 ± 0.32mg/dl and
HDL-C=1.47 ± 0.15mg/dl) when compared with the group 1(TC=9.92 ± 1.02mg/dl, TG=3.18 ± 0.26mg/dl, LDL-C=7.74 ±
1.86mg/dl, VLDL-C=1.11 ± 0.12mg/dl and HDL-C=1.08 ± 0.11mg/dl,). Consequently, treatment with the fractions and
standard drug reverse the alloxan effect. This study thereby indicates that ethyl acetate leaf fraction of Gongronema latifolium
may exert a hypoglycemic effect and could improve the lipid profile concentrations in diabetic rats.
Cynarin inhibits melanogenesis through ERK signaling pathway on α-MSH-induced melanin
biosynthesis
Gyoseon Goya M Ryeom, Hae Yeon Kim and Young Bu Kim
iPEERES Cosmetics Ltd., Republic of Korea
C ynarin is composed of plant such as artichoke, sunflower seed and burdock. These materials have compound such as
chlorogenic acid (Caffeoylquinic Acid), caffeic acid, cynarin (Dicaffeoylquinic Acid), quercitrin (Quercetin Rhamnoside),
arctiin, quercetin, luteolin. They provide special bio-physiological effect: chlorogenic acid, caffeic acid, quercitrin and luteolin
as anti-melanogenesis factor; arctiin as inflammatory regulator (MAPK related factor) or protector from UVB-induced stress
and so on. However, it has not been reported yet for melanogenesis biosynthesis of cynarin as component of these plants.
Therefore, we also investigated melanogenesis of cynarin via signaling pathway. Melanogenesis-related protein as MITF,
tyrosinase were decreased by cynarin via ERK signaling pathway in α-MSH-induced human melanoma cells (MNT-1). Cynarin
has also represented inhibition of melanin content and intracellular tyrosinase activity. Cynarin is being provided at anti-
melanogenesis or anti-pigmentation factors because of its investigated anti-melanogenesis mechanism in α-MSH-induced
human melanoma cell and are well worth enough.
American Journal of Ethnomedicine, 4:2
DOI: 10.21767/2348-9502-C1-003