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Volume 4, Issue 2 American Journal of Ethnomedicine
ISSN 2348-9502
Natural Products Congress & World Pharma Congress 2017
October 16-18, 2017
3rd World Congress on
NATURAL PRODUCTS CHEMISTRY AND RESEARCH
&
12th WORLD PHARMA CONGRESS
October 16-18, 2017 Budapest, Hungary
Effects of ethanolic extract of Rauvolfia vomitoria (Apocynaceae) stem bark on sexual behavior and
reproductive function in normal male rats
Koloko Brice L1,2, Kenmogne Hubert1, Ngaha Njila M1, Bogning Calvin1, Wankeu Modeste1, Bushra Ijaz2, Dongmo Alain1 and Massoma Dieudonné1
1University of Douala, Cameroon
2University of the Punjab, Pakistan
Objective: This study was aimed to investigate the effect of ethanolic extract of Rauvolfia vomitoria stem bark on sexual
behavior and male reproductive function in normal rats.
Methods: 25 healthy sexually experienced Albino male rats of 3-4 months, weighing between 190 and 220 g were randomly
divided into five groups (A–E) of five rats each and orally treated once daily for 22 days. Group A (control) received 5 mL/
kg body weight of distilled water, groups B, C and D received 50, 100 and 200 mg/kg BW of Rauvolfia vomitoria extract
respectively, while group E received 5 mg/kg BW of sildenafil citrate (standard). Sexual behavior parameters including mount
frequency (MF), intromission frequency (IF), ejaculation frequency (IF), mount latency (ML), intromission latency (IL),
ejaculation latency (EL) and post-ejaculatory interval (PEI) were recorded in male rats one hour after treatment by mating
with a receptive female (1:1) at day 0, 1, 8, 15 and 22. At the end of treatment, body and organ weights, histological analysis
and sperm parameters were also evaluated.
Results: The treatment with Rauvolfia vomitoria extract improves sexual behavior through significant reduction of ML, IL and
PEI (p<0.01) and significant increase of EL, IF and EF (p<0.01) as compared to control. The extract also significantly increased
daily sperm production rate (DSP) and epididymal sperm counts (p<0.001) as well as sperm transit (p<0.05) compared to
control. Testis histology showed that the extract increased the concentration of all germ cell types, Leydig cells and Sertoli cells
as compared to control.
Conclusion: Present findings provide experimental evidence that the ethanolic extract of Rauvolfia vomitoria enhances male
sexual activity and production function in rats.
Fiber based drug delivery system concepts and engineering
Z Ahmad
De Montfort University, UK
The role of structure in drug delivery system engineering has become more diverse over the few decades or so. In recent
times, there has been an interest in not-particulate systems for the development of drug delivery systems, which has arisen
from the need to improve physical and chemical interaction properties with the host environment. To this end, there has been
a significant increase in the deployment and engineering of fiber based systems as potential drug delivery carriers. Several
methods have been explored and electrospinning technology, amethod to engineer such structures, has gainedmuch popularity
over the last decade. This talk will focus on the electrospinning technique which belongs to the Electrohydrodynamic (EHDA)
family of processes. Fundamental principles will be discussed and key developments in the area will be shown. Furthermore,
concepts relating to compartmentalization and upscale will be presented. Finally, examples of ongoing developments between
industry and academia will be highlighted, showing collaboration between industry and academia.
American Journal of Ethnomedicine, 4:2
DOI: 10.21767/2348-9502-C1-003