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Biochem Mol biol J
ISSN: 2471-8084
Volume 3, Issue 2
Metabolomics Conference 2017
August 29-30, 2017 Prague, Czech Republic
9th International Conference and Exhibition on
Metabolomics and Systems Biology
Notes:
Page 34
APC as an entry point to study small molecule
regulation of the cell cycle
Nubia Barbosa Eloy
Max Planck Institute, Germany
The anaphase-promoting complex/cyclosome (APC/C)
is a multi-subunit E3 ubiquitin ligase that plays a major
role in the progression of the eukaryotic cell cycle. This
unusual protein complex targets key cell-cycle regulators,
such as mitotic cyclins and securins, for degradation
via the 26S proteasome by ubiquitination, triggering the
metaphase-to-anaphase transition and exit from mitosis.
The identification of the complete set of genes encoding
subunits of the APC in Arabidopsis suggests that the basic
processes controlled by proteolysis mediated by ubiquitin
in plants are similar to those of other organisms. However,
results from several groups indicate that theAPC has other
specific functions in the regulation of plant development.
During the last years, several molecular-biology tools
have been extensively used in scientific research for
identifying new function of proteins and metabolites.
Still, the identification of metabolites, specially which
control the cell cycle is not trivial and is characterized by
piecemeal progress, especially in plants. In this seminar,
we will discuss the methodologies that we are using to
identify and characterize metabolites that bind to the APC
in the model plant Arabidopsis, and to potentially define
their roles in plant development.
Biography
Nubia Barbosa Eloy has her expertise in Plant Development and Cell Cycle,
especially in improving the ways to have better crop and production. During
her academic life, she has published several peer reviewed papers about
plant growth and development. Her main interest is to study the plant growth
to better enhance crop productivity, using cutting edge techniques to achieve
her goal.
Nubia Barbosa Eloy, Biochem Mol biol J, 3:2
DOI: 10.21767/2471-8084-C1-002