Confluence of Biological Researches for Cure and Therapeutics: An Initiative from Molecules to Medicine

Ravi Kant Upadhyay*

Department of Zoology, Deen Dayal Upadhyaya Gorakhpur University, Gorakhpur-273009, UP, India

*Corresponding Author:
Ravi Kant Upadhyay
Department of Zoology
Deen Dayal Upadhyaya Gorakhpur University
Gorakhpur-273009, UP, India
Tel: 05512205616
E-mail: rkupadhya@yahoo.com

Received date: 27 September 2017; Accepted date: 10 October 2017; Published date: 13 October 2017

Citation: Upadhyay RK (2017) Confluence of biological researches for cure and therapeutics: an initiative from molecules to medicine. J Biol Med Res. Vol.1 No.1: e005.

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Abstract

In modern age large section of human society is facing ill effects of environmental stress and high morbidity due to presence of diseases, pathogens and pollutants in the surroundings. Global climate change is imposing three long range effects i.e. lethality, post disease morbidity and rising resistance in pathogens against drugs/antibiotics. There is a need to develop new methods, technologies, low toxic and safer formulations to combat insect vectors on one hand, and diagnosis methods in disease strains on the other.

Editorial

In modern age large section of human society is living in polluted surroundings and facing ill effects of environmental stress and high morbidity due to presence of disease pathogens and pollutants in his surroundings. Global climate change is imposing three long range effects lethality, post disease morbidity and rising resistance in pathogens against drugs/antibiotics. After seeing rising trends of disease transmission, morbidity and lack of quick diagnosis, and availability of appropriate drug regimens and methods of drug delivery, severity of infection, lethality and morbidity rate has been increased. There is need to develop new methods, technologies, low toxic and safer formulations to combat insect vectors on one hand, and diagnosis of mutation in disease strains on another. To find solutions of drug and pesticide resistance novel bioorganic compounds from plant origin are to be used for making broad spectrum nano-herbal drug formulations and complexes of green chemicals be used to fight against drug resistance and insecticides resistance. From plant products series of chemo preventive anti-cancer drugs can be prepared. There is rising demand low toxic and safe vector control agents, herbal compounds for making therapeutic drugs and pure antigens to synthesize vaccines for encephalitis, malaria, filarial, cell culture based vaccines. Thus, for better management of communicable and life style diseases, congenital disorders and other pathogenic conditions the there is a need to integrate all existing therapeutic methods, diagnostics and do make advancement of technology to find mutations and prepare medicines accordingly. From researches it has been well established that plant based herbal medicines showed better potential to curb on resistant pathogens, no doubt these are good alternate of less effective and old drug formulae. These are easy to catabolize, less toxic and impose no long term cumulative side effect in patients. Now green chemicals are used to prepare non-toxic Met-NPs (metallic nanoparticles) which are easy to transfer drug and target specific. These also serve as excellent CT/photoacoustic contrast-enhancement agents and show high diagnostic specificity, usage and assist in drug assimilation from where it reaches to target organ system. For achieving better therapeutic success existing outcomes of medical, clinical biological researches should be integrated with biophysics, molecular biology, pharmacology and bioinformatics to enhance application of various molecules to make quality medicines, ultra-modern diagnostics, and more advanced drug delivery methods. With technological advancements new judicious laws, practices, policies, aids, taxes, insurance and all-round reforms be needed to upgrade the health system.

There is another area which can assist in disease therapeutics mainly cancer. There are several toxins/proteins and peptides have been isolated from animal venoms which show novel cytotoxicity to cancer cells and potentially inhibit growth of microbes. Venom toxin short peptides and their analogues can be used to design a new generation of specific inhibitor of human angiogenesis. These can also inhibit progression of cancer and affect cyclin function. T cell proteome for wasp venom can facilitate the future development of T cell-based immunotherapeutic approaches. Development of drug delivery systems can be made by using toxin components to prepare Nano scale therapeutic devices to target brain tumors, breast, colorectal cancer and oral cancers. Encapsulated animal venoms exhibit better efficacy and act more vigorously as an anti-cancer agent against cancer and cancer cell lines. Structural modifications in venom toxins/ proteins/peptides can be used to make new drug templates which may accelerate interactions between pathogen and receptor cells. Thus, by altering hydrophobic interactions and insertion of new amino acids in active site region of toxins/ proteins more potential therapeutic drug molecules can be generated. But for finding sole reasons of disease structural studies are needed in the field pathology and therapeutics to establish disease causing genes and mutations in structural molecules. For better studying the clinical aspects of microbes and therapeutics nature of drug, drug-receptor interactions must be fully explored. For therapeutic purposes marine plants and animals can assist as rich source for preparation of more effective pharmaceuticals of low dosage and low toxicity. For finding better solutions through bio-informatics computational/mathematical integration with biological and physical sciences is highly needful. In silico molecular studies can assist in finding quick solutions for diagnosis and treatment of diseases.

Due to increase in level of various pollutants in environment neuro-sensory problems are increasing day by day. For healing and therapeutics of important visual, hearing, nasal and neuronal defects/disorders new methods and therapeutic molecules are in high demand. Stem cells and their transplantation can help to retrieve sensory receptor functions. For finding quick solutions sensory-neuronal disorders new diagnostic and therapeutic methods are needed. Besides stem cell transplantation, new biomaterials, cell scaffolds and concurrent efforts are needed. However, for restoration of pathological and congenital disorders and diseases new cell culture and transplantation methods, biocompatible substrates, bio-matrix, and micro-niche maintaining factors are more essentially needed for repairing and healing of sensory epithelial cell successfully. For tissue repair, wound healing and regeneration there is a need to design new biomaterials to make matrix based nano-structure constructs for sensory cell. For achieving quick therapeutic solutions other than use of drugs, surgery is an important method to treat a disease, cure illness and soon get red from pathological condition. Some of the acute and chronic diseases can be cured only by surgeries.

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