To evaluate sequential changes in biochemical bone parameters, parathyroid hormone (iPTH), and vitamin D levels over a period of 24 weeks after renal transplantation, we studied 52 patients (41 males, with a mean age of 31.98.) who underwent their first renal transplantation without a past history of parathyroid surgery or fractures. Serum calcium, phosphorus, albumin, Serum iPTH and vitamin D levels were measured before transplant, then at 2, 4, 12 and 24 weeks post transplantation. Serum calcium showed a significant increase from 2 to 12 weeks after transplantation, followed by a slight decline until 24 weeks. At the end of 12 and 24 weeks, 6 (11.53%) and 2 (3.8%) patients had hypercalcemia respectively.