Abstract

Amyotrophic Lateral Sclerosis (ALS) is a malignant disorder in body which impairs motor neuron activity of body and eventually causes death. Although, many researches have been allocated to discover the molecular basis of ALS, but no definite cure of this fatal disease has been found until present time. The scientific revolution of application of stem cells in medicine has encouraged utilization of such technology to exploit the related medical benefits in ALS therapeutics. The purpose of this review is to explore in detail of any available findings of pre-clinical and clinical expeditions of the medical effects of Mesenchymal Stem Cells (MSCs) on ALS.

The review encircles in detail the medical research findings on the immune effects of MSCs in ALS treatment and also the related clinical trial. Also the wide range of overall world impact of the disease at present time and in the future is reviewed. permeability parameters and ADC, irrespective of the brain We describe a case of a 13 years old girl who developed L3-L4 spondylodiscitis by Staphylococcus aureus agent. After 2 months of levofloxacin therapy she developed intracranial hypertension, without any evidence of intracerebral mass or hydrocephalus at CT scan and MRI. The levofloxacin therapy was stopped and the symptoms disappeared after same days.