Where Darwin neglected to explain the human-brain encephalization Part 3: Data of a supportive C57bl6 mouse model following a Systems Biology lipidomics based approach

In an earlier study we observed at a High-fat diet induced obese C57bl6 mouse model with "overgrown brain" or “brain steatosis”. Here our observations are indicative that mainly unsaturated very long chain fatty acids (TGs) of the C: 50, C: 52 and C: 54 TGs fraction were accumulated in the HF-diet obese C57BL6 whole brain fraction and we found based on LC-MS techniques a close correlation with the nutritional composition of the HF diet with respect to these TGs of the HF feed diet (correlation coefficient r2 = 0.760 compared to control group r2 = 0.264) Thus, from these observations, we concluded that a juvenile rodent study in bovine-induced obesity exhibited an "overgrown brain", primarily through the accumulation of triacylglycerols (TGs). From these observations we suggested and proposed the hypothesis that the specific molecular structure of bovine lard with large amounts of unsaturated C: 50; C: 52 and C: 54 TGs could have played a role in the encephalization of mammals. As a follow-up to this study, our main interest in this study can be defined as similar observations are made in humans. We also described, via the principle of hunter- prey correlation, similarities in migration routes of the ancestors of the herds of the African buffalo (Syncerus caffer), mitochondrial-DNA studies) and these of early hominids (paleontological- & archaeological studies. So, in this third review with mainly data of a C57bl6 mouse model we intend to find an explanation and most important try to unravel any mysteries related to the specific composition of bovine lard or meat in relation to the process of human encephalization.

Author(s): Vincent van Ginneken

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