Abstract

Aging is a multifactorial biological process characterized by reduced lifespan and progressive functional decline. Developing strategies that can both extend lifespan and maintain physiological function has become an important research focus. S. Involucrata Stem Cell Extract (SISCE), rich in polyphenols and flavonoids, has potential for health-related applications, while Vitamin C is a widely used functional ingredient. To evaluate the effects of SISCE alone and in combination with Vitamin C on lifespan and locomotor activity in C. elegans. Age-synchronized wild-type N2 C. elegans were randomly assigned to control, SISCE and SISCE + Vitamin C groups. Lifespan was analyzed using Kaplan–Meier survival analysis. Locomotor activity was assessed to evaluate age-related functional changes and mobility duration and decline slope were calculated. SISCE significantly increased mean lifespan from 20.16 to 23.38 days (+16.0%, p = 0.005). Co-treatment with Vitamin C further extended lifespan to 24.41 days (+21.1%, p = 0.0001). Both treatments significantly attenuated age-related decline in locomotor activity, with the combination group showing the greatest effect. Mobility duration increased from 5.1 days to 8.5 days (+66%) and the decline slope was reduced, indicating a slower rate of functional deterioration. SISCE extends lifespan and improves locomotor function in C. elegans and these effects are enhanced when combined with Vitamin C. This combination shows potential as a functional ingredient for applications in healthy aging and warrants further investigation.

Author(s): Chi-Fu Chiang, Li-sheng Lee, Yung-Hsiang Lin, Yung-Kai Lin, Shu-Ting Chan

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