A simple, precise, accurate spectrophotometric method was developed and validated for the determination of Lurasidone HCl in bulk and pharmaceutical formulations. Beer's law is obeyed in the concentration range of 2-10 μg/mL with good correlation coefficient (R2= 0.9995) and UV detection was done at 315 nm. The percentage recovery studies were performed and the percentage recovery was found to be of 98.76 -99.84 %. The method was precise and the relative standard deviation was found to be 0.98. Detection limit and Quantitation limit were found to be 0.253 μg/mL and 0.766 μg/mL respectively. The proposed method was successfully validated as per the ICH guidelines. This method can be used for the determination Lurasidone HCl in quality control laboratories without interference of excipients.