Exosomes are extracellular vesicles that carry a cargo of therapeutic proteins, which have shown promising potential in regenerative medicine applications. However, there remains an unmet need to optimize their therapeutic effect. One potential avenue of optimization lies in ultrasound, a non-invasive technique where sound waves are focused onto a tissue-of-interest. It has previously been demonstrated that ultrasound can enhance the therapeutic effect of stem cell therapies. However, the effect of ultrasound on exosome therapy remains largely unexplored. In the present study, we analyzed the effect of exosome therapy, combined with ultrasound. Exosomes significantly improved the repair process of damages tissues. This protective effect was mediated by a reduction in inflammation, increased cell proliferation, and decreased apoptosis. We identified several pathways through which exosomes and ultrasound synergistically exert their therapeutic effect, including upregulation of CD9 signaling. Thus, ultrasound may be a promising strategy for enhancing the therapeutic efficacy of exosome treatment.
Journal of Cell and Developmental Biology received 54 citations as per Google Scholar report