ULPC-MS/MS phenolic quantification and in vitro anticancer potential of Gmelina arborea Roxb. (Verbenaceae)

Phenolic secondary metabolites are recognized as excellent antioxidants and are subject of numerous scientific studies. The present study was aimed firstly, to quantify the phenolic constituents contained in the hydroacetonic crude extract obtained from Gmelina arborea leaves by UPLC-MS/MS and secondly, to investigate in vitro its anticancer potential against 6 cancerous cell lines. The quantitative analysis revealed a significant abundance in flavonoids (75.50%) and a presence of hydroxycinnamic acid derivatives (24.49%). The results of cytotoxicity survey clearly indicate that the hydroacetonic crude extract shows a good anticancer activity against C6 glioma cells.

Author(s): K. C. C. N’gaman, G. R. M. Kabran, B. A. Kadja, J. A. Mamyrbékova-Békro, J. L. Pirat, Marc Lecouvey, Odile Sainte-Cathérine, Nicolas Sommerer, Arnaud Verbaere, Emmanuelle Meudec and Y. A. Békro

Abstract | PDF

Share This Article