Thienopyrimidines as novel anti-inflammatory agents and antioxidants

Thienopyrimidines, formed by the fusion of thiophene moiety with pyrimidine ring, have been reported to have wide variety of biological activities . The present work is an effort towards the evaluation of some new 4,5-unsubstituted thieno[2, 3-d]pyrimidine derivatives 7(a-l) as antiinflammatory and antioxidant agents. Nine compounds (except 7h, 7k, 7l) were subjected to in vitro anti-inflammatory activity using bovine serum albumin denaturation model. Except compounds (7a and 7l) all seven compounds exhibited good anti-inflammatory activity. All the compounds 7(a-l) were evaluated for in vitro antioxidant activity. Only two compounds (7i, 7l) shown moderate free radical scavengering activity. Though compounds have exhibited weak antioxidant activity, it could be taken as advantage with mainstream anti-inflammatory action. This study proves that the class of thienopyrimidines can potentially serve as lead structure for further optimization because of their dual action as antioxidants and anti-inflammatory agents

Author(s): Rashmi P , Laxmivenkatesh G. Nargund and Kuntal Hazra

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