Thermodynamic studies of transition metal complexes with Metformin Hydrochloride drug in 20 % (v/v) ethanol-water mixture

pH metry is one of the most convenient and successful technique employed for metal complex equilibrium measurements. In the present work we investigate the stability constant of Metformin Hydrochloride drug with transition metal ions Fe(III),Co(II),Ni(II),Cu(II),Zn(II) &Cd(II) using PH metric technique in 20%(v/v) ethanolwater mixture at 298K,308K ,318K and at an ionic strength of 0.1M NaClO4. The method of Calvin and Bjerrum as modified by Irving and Rossotti has been employed to determine metal-ligand stability constant (logK) values. It is observed that a transition metal ion forms 1:1 and 1:2 complexes. The thermodynamic parameter
G,
H and
S were calculated from values of stability constant at different temperatures. The formations of metal complexes were found to be spontaneous and exothermic in nature

Author(s): Shailendrasingh V. Thakur a, Mazahar Farooqui b and S. D. Naikwade

Abstract | PDF

Share This Article