Safe water constitutes major resources to meet the requirements of basic hygiene that are necessary in curtailing the spread of COVID-19. This study reviewed COVID-19 Pandemic and its attendant problems. The role of safe water in ameliorating the deadly effects of COVID-19 is discussed. Literature search was the major methodology to this review. Results revealed that devastating Pandemics including Bubonic plague and small pox, killing 200 million and 56 million people respectively have been reported in literature. Only 83,600 deaths were reported globally due to COVID-19 as at April 2, 2020. Two main possible sources of the Pandemic are natural source and transmission through bats and/or pangolins. Respiratory droplets are believed to be the most common mode of coronavirus transmission. No vaccine has been developed for COVID-19. To mitigate the Pandemic; maintain social distancing, avoid hands shake/hugging; constantly wash your hands under running taps and rub hands with sanitizer. There is no current evidence that corona viruses are present in surface/groundwater but controlling the spread of the virus is closely related to water and sanitation. COVID-19 has negatively impacted humans’ health and the globe’s economy. Preventing COVID-19 is feasible if the global humans’ requirement for safe water is attained.