The PI3K/Akt Signalling Pathway Plays Essential Roles in Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) can self-renew and maintain a multi-lineage differentiation potential. The PI3K/Akt signalling pathway is an essential signalling pathway of protein synthesis with complicated downstream activity. This review attempted to explore whether and how the PI3K/Akt signalling pathway influences MSCs. We concluded that MSCs participate in the proliferation, differentiation, mobilization, homing, senescence and apoptosis of mesenchymal stem cells. Mesenchymal stem cells (MSCs) can protect damaged cells through the PI3K/Akt signalling pathway, making it potentially useful in regenerative medicine and chronic diseases, such as ischaemic heart disease, end-stage liver disease, and ischemic stroke. The roles of the PI3K/Akt signalling pathway in MSCs were partly revealed, and more studies are needed. With further understanding of the detailed mechanisms involved, we can treat disease accurately and effectively.

Author(s): Cuncan Deng, Guihua Liu

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