Taste masked resinates of cefpodoxime proxetil using ion exchange resins

Cefpodoxime proxetil is a third generation broad spectrum β-lactam cephalosporin class of antibiotic administered orally in pediatric and adult patients and is extremely bitter in taste. Masking bitter taste is a major challenge for better patient compliance particularly in an antibiotic treatment where dose and duration is important. Among the various techniques available for bitter taste masking, ion exchange resin is a popular approach as it has significant advantages over other techniques. In the present study resinates of cefpodoxime proxetil were formulated using anion exchange resin Duolite AP143 and cation exchange resin Kyron T-104. Resinates were prepared in various drug: resin ratios using batch method. The prepared resinates were characterized for FTIR, DSC, and SEM studies. The release rate of Duolite AP143 resin in the ratio of 1:2 Drug: resin complex showed identical release profile. Taste masking was done with increase in the ratio of resin.

Author(s): Vijender E

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