Tamarind juice catalyzed one pot synthesis of dihydropyrimidinone and thione under ultrasound irradiation at ambient conditions: A green approach

Application of fruit juice as a natural and biocatalyst allows mild and highly selective transformation and synthesis in a facile and environmentally friendly manner. Moreover, fruits are inexpensive and easily available in the market, the extracted juice can be easily used as catalyst in the organic transformations. Tamarind juice catalyzed synthesis of dihydropyrimidinone and thione (DHPMs) derivatives were accomplished via Biginelli reaction between substituted aryl aldehydes, ethyl acetoacetate and thiourea/urea under ultrasound irradiation at ambient conditions. The tamarind juice can be simply prepared from fruit of Tamarindus indica in water and the reactions go to completion under ultrasound irradiation within few minutes with excellent yield. This approach is totally non polluting having several advantages such as shorter reaction time, mild reaction conditions, simple workup and moreover a green approach.

Author(s): G. M. Nazeruddin

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