Synthesis of substituted 2-Azetidinones based on 1-N-phenyl-3-phenyl-4- formyl pyrazole (PFP)

Tri ethyl amine (TEA) and chloroacetyl chloride with Schiff base (amino-sulfonamide derivatives) constitute an interesting class of organic compounds with diverse pharmacological applications including antimicrobial activity. (1E)-1-(phenyl)-ethanone-(phenyl)-hydrazone with mixture of Vilsmeir-Haack reagent affords the corresponding 1- N-phenyl-3-phenyl-4-formyl pyrazole (PFP) and further reaction with different amino-sulfonamide derivatives so make a Schiff base and finally new potentially active compound are prepared by condensing these 3-chloro-4-[1-Nphenyl- 3-phenyl-pyrazole]-1-N-substituted-phenyl benzene sulfonamide-azetidin-2-ones with tri ethyl amine (TEA) and chloro acetyl chloride. 1 H NMR, IR, Mass spectra and elemental analysis, has established the structures of all the newly synthesized compounds.

Author(s): Kokila Parmar, Shashikant Sutariyaa, Kalpeshgiri Goswamia and Yogesh Dabhib

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