Synthesis, characterization and biological studies of novel azetidinones

2-(5-(phenoxy methyl)-2-thioxo-1,3,4-oxadiazol-3(2H)-yl)acetohydrazide(1) undergoes facile condensation with aromatic aldehydes to afford the corresponding N'-aryl-2-(5- (phenoxymethyl)-2-thioxo-1,3,4-oxadiazol-3(2H)-yl)acetohydrazide (2a-h) in good yield. Cyclocondensation of compounds (2a-h) with chloro acetyl chloride yields N-(3-chloro-2-aryl-4- oxoazetidin-1-yl)-2-(5-(phenoxy methyl)-2-thioxo-1,3,4-oxadiazol-3(2H)-yl)acetamide (3a-h). The structures of these compounds were established on basis of analytical and spectral data. The newly synthesized compounds were evaluated for their antibacterial and antifungal activities

Author(s): R. R. Mishraa\ ,K. S. Nimavatb and K. B. Vyasc

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