Synthesis, characterization and anti-oxidant, anti-inflammatory activities of some novel chalcones and 1,3,5-trisubstituted pyrazolines

A systematic investigation of pyrazoline class of heterocyclic lead revealed that pyrazoline containing pharmacoactive agents play important role in medicinal chemistry. Some new1-[3-(2,4-dichloro-5-fluorophenyl)-5- (aryl)-4,5-dihydro-1H-pyrazol-1-yl] ethanone derivatives were synthesized by reacting chalcones derivatives with hydrazine hydrate in glacial acetic acid. The structural elucidation of compounds was confirmed by 1H NMR and IR analysis. The synthesized compounds were screened for the antioxidant activity by DPPH method and Hydrogen peroxide method. Also the synthesized compounds were screened for the anti-inflammatory activity by egg albumin denaturation method and Heat induced hemolytic method.

Author(s): L. Siva Sanker Reddy, T. Rajkumar, K. Jyothi and Y. Siva Rami Reddy

Abstract | PDF

Share This Article
30+ Million Readerbase
Google scholar citation report
Citations : 374

Der Pharmacia Sinica received 374 citations as per google scholar report

Abstracted/Indexed in
  • Google Scholar
  • Genamics JournalSeek
  • China National Knowledge Infrastructure (CNKI)
  • Directory of Research Journal Indexing (DRJI)
  • Proquest Summons
  • International Committee of Medical Journal Editors (ICMJE)
  • Serials Union Catalogue (SUNCAT)
  • Geneva Foundation for Medical Education and Research
  • Secret Search Engine Labs

View More »

Flyer image