Synthesis, characterization and antimicrobial activity of novel mannich bases

In the present work, some Mannich bases are synthesized by treating morpholine and thiophene-2-aldehyde as fixed components and varying compounds containing active hydrogen atoms. The synthesized compounds were characterized by spectral (IR, 1H NMR, 13C NMR and GC MS) and analytical (elemental analysis, melting point and TLC) techniques. The synthesized compounds were screened for antimicrobial activities against certain bacteria (Staphylococcus aureus, Streptococcus faecalis, Escherichia coli & Pseudomonas aeruginosa) and fungi (Candida albicans & Aspergillus niger) and found to exhibit significant activities

Author(s): S. Arun Prabhua, A. Abdul Jameelb and M. Syed Ali Padushac

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