Synthesis and evaluation of 1-(2-(Substituted benzylidenehydrazinyl)acetyl)3(hydroxyimino)indolin-2-one as potential anticonvulsants

On the basis of pharmacophore model and essential parameters for anticonvulsant activity, a series of 1-[2- (substituted benzylidenhydrazinyl)acetyl]-3-(hydroxyimino)indolin-2-one (4a-4n) were designed and synthesized starting from isatin. The structures of synthesized compounds were confirmed by elemental and spectral analysis. All the compounds were evaluated for their anticonvulsant activity by MES induced seizure model and their neurotoxic effects by rotarod test. Most of the compounds showed moderate to good activity at the dose 30 and 100 mg/kg without neurotoxicity and produced neurotoxicity at 300 mg/kg.

Author(s): Nadeem Siddiqui, Pankaj K Singh, Nitin Kumar and Devender Pathak

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