The main objective of the medicinal chemistry is to synthesize the compounds that show promising activity as therapeutic agents with lower toxicity. In the current research work, the title compounds N`[substituted sulfonyl]-1,3-benzoxazole-5-carbohydrazide, were synthesized by electrophilic aromatic substitution on p-hydroxy methyl benzoate (I) with concentrated nitric acid and concentrated sulfuric acid under reflux condition. Compound (II) on reduction with sodium dithionate with alcohol gives 3-amino-4-hydroxy-benzoic acid methyl ester (III). Reaction of compound (III) with two appropriate aliphatic acids (formic acid and acetic acid) produced corresponding 2-subtituted benzoxazole-5-carboxylic acid methyl esters. The reaction of compounds (IV) with hydrazine hydrate in ethanol on refluxing yielded the corresponding 2- substituted benzoxazole-5-carboxylic acid hydrazides. On further reaction of compounds (V) with the different sulfonyl chloride derivatives afforded the corresponding eight N`[substituted sulfonyl]-1,3-benzoxazole-5-carbohydrazide. The identification and characterization of the synthesized compounds were carried out by Elemental analysis, melting point,Thin Layer Chromatography, FT-IR, NMR and Mass data to ascertain that all synthesized compounds were of different chemical nature than the respective parent compound.