Synthesis and characterization of flavanone derivatives and 3,5-diaryl-4-aroyl isoxazolines

A series of 3, 5-diaryl-4-aroyl isoxazolines (5 a-f) have been synthesized by cyclization of bromo nitro substituted Flavanones (4 a-f) with hydroxylaminehydrochloride in pyridine containing few drops piperidine. These substituted flavanones have been prepared by interaction of 1-(2-hydroxy-3-bromo-4-nitro-5-methylphenyl)-3-phenyl-1, 3- propanedione with different substituted aromatic aldehydes refluxing in ethanol with 0.5 ml piperidine. Constitutions of synthesized compounds have been confirmed on the basis of elemental analysis (CHN), MASS, IR and 1H NMR spectral analysis.

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