Synthesis and antimicrobial studies of novel heterocyclic compounds containing piperazine ring

1-(4-aminophenyl)-2-(4-ethylpiperazin-1-yl)ethanone (1) undergoes facile condensation with aromatic aldehydes to afford the corresponding 1-(4-(arylideneamino)phenyl)-2-(4-ethylpiperazin-1-yl)ethanone (2a-h) in good yields. Cyclocondensation of compounds (2a-h) with thioglycolic acid yields 2-aryl-3-(4-(2-(4-ethylpiperazin-1- yl)acetyl)phenyl)thiazolidin-4-one (3a-h). The structures of these compounds were established on the basis of analytical and spectral data. All the newly synthesized compounds were evaluated for their antibacterial and antifungal activities.

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