Synthesis and antimicrobial screening of some N-(4-oxo-2-alkyl/aryl-thiazolidine-3-yl)isonicotinamide derivatives

Some new N-(4-oxo-2-alkyl/aryl-thiazolidine-3-yl) isonicotinamide derivatives of isoniazid have been synthesized and evaluated for their Anti-bacterial, Antifungal and Anti-tubercular activity. Synthesized compounds showed significant activity against bacterial, fungal and mycobacterium strains. Their structures were established on the basis of elemental analysis, IR, 1H NMR and Mass Spectral data.

Author(s): *Rakesh Patel1 and Anil Bhandari2

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