Synthesis and antimicrobial properties of novel 2,5-disubstituted 1,3,4-oxadiazoles

The search for better antimicrobial agent due to rapid appearance of multidrug resistant microorganism and antimicrobial properties of semicarbazones and 2,5-disubstituted 1,3,4-oxadiazoles prompted us to undertake the synthesis of a few novel N1-[5-(4-substitutedphenyl)-1,3,4-oxadiazol-2-yl]-N4-(4- substitutedbenzaldehyde)-semicarbazone and N1-[5-(4-substitutedphenyl)-1,3,4-oxadiazol-2-yl]-N4-[1-(4- substitutedphenyl)ethanone]-semicarbazone hitherto unreported for their antimicrobial activity. The structures of the compounds were elucidated by elemental and spectral (IR, 1H NMR, 13C NMR and MS) analysis. The antimicrobial potential of the compounds was investigated using disk diffusion method. Compound VI(o) was found to possess significant antimicrobial activity during antimicrobial evaluation. Compound VI(m), VI(n) and VI(p) also demonstrated marked antimicrobial property. Structure-activity relationships among synthesized compounds were also established.

Author(s): Harish Rajaka , Bhupendra S. Thakura, Poonam Parmara, Pramod Kumara, Arun K Guptab,Navneet Agrawalc and Ravichandran Veerasamyd

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