Synthesis and antimicrobial activity of new pyridines fused with naphtho[2,1-b]furan

A series of 2-amino-4-(phenylsubstituted)-6-naphtho[2,1-b]furan-2-ylnicotinonitrile derivatives 4(a-g) have been prepared by the cyclocondensation of malononitrile, aromatic aldehyde and ammonium acetate with 2-acetylnaphtho[2,1-b]furan. The similar reaction of 4(a-g) with alcoholic KOH and phenylisothiocyanates resulted in the formation of various 2-amino-6-(1,2-dihydronaphtho[2,1-b]furan-2-yl)-4-phenylsubstitutedpyridine-3- carboxamides 5(a-g) and 6-{[-3-(phenylsubstituted)-1-( naphtho[2,1-b]furan-2-yl)but-2-en-1-ylidene]amino}-4- imino-3-phenyl-3,4-dihydro pyrimidine-2(1H)-thione derivatives 6(a-g) respectively. The structures of the newly synthesized compounds have been established on the basis of analytical and spectral data. The synthesized compounds have been screened for antimicrobial activity

Author(s): Chandrashekhar C. H.1, Latha K. P.1, Vagdevi H. M.1, Vaidya V. P.2 and Vijaya Kumar M. L.3

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