Synthesis and antibacterial screening of some 1-phenyl-3-aryl-5-(4-(4-butanoloxy) phenyl)-1H-pyrazoles

A series of 1-phenyl-3-aryl-5-(4-(4-butanoloxy) phenyl)-1H-pyrazoles were synthesized from chalcones and screened for their in vitro antibacterial activity. Chalcones i.e.,1-aryl-3-(4-hydroxyphenyl) prop-2-en-1-ones, 1 on reaction with phenyl hydrazine in presence of acetic acid and few drops of hydrochloric acid furnished the corresponding 1-phenyl-3-aryl-5-(4-hydroxyphenyl)-1H-pyrazoles 2 which on further reaction with 4-chlorobutanol yielded the title compounds 3. These compounds were characterized by CHN analyses, IR, mass and 1H NMR spectral data. All the compounds were studied for their in vitro antibacterial activity against two Gram positive strains (Bacillus subtilis and Staphylococcus aureus) and two Gram negative strains (Escherichia coli and Pseudomonas aeruginosa) and their minimum inhibitory concentration (MIC) were determined.

Author(s): Anju Goyal, Neelam Jain and Sandeep Jain

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