Synthesis and antibacterial activity of pyrimido[5, 4-c]quinolin-2,5-dione
and their derivatives

Arumugam Murugesh; Sangeetha Subramaniam; Subramanium Parameswaran Rajendran

Abstract

Synthesis and antibacterial activity of pyrimido[5, 4-c]quinolin-2,5-dione and their derivatives

Novel pyrimido[5,4-c]quinolin-2,5-dione (5a-f) were obtained from the precursor 2, 4-dichloro-3-formylquinolines (2a-f) which in turn were synthesized by using Vilsmeir adduct with 4-hydroxyquinolin-2(1H)-ones (1a-f) [18]. Most of the compounds were screened for in vitro growth inhibitory activity against Escherichia coli, Shigella dysenteriae and Klebsiella pneumoniae

Author(s): Arumugam Murugesh, Sangeetha Subramaniam and Subramanium Parameswaran Rajendran

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