Study of the effect of ethanolic extract of Solanum xanthocarpum schrad & wendl on Glu-4 and PPARγ gene expression in L6 cell lines

Solanum xanthocarpum is a plant used in traditional and Alternative medicine in India and other parts of the world. The present study is aimed at investigating the effect of the ethanolic extract (SXA) on GLUT-4 and PPARγ gene expression. Type 2DM and obesity are associated with impairment in the regulation of GLUT 4 gene expression and elevated levels of free fatty acids. An increase in the expression of GLUT-4 gene is an index of adaptation to enhanced metabolic demand and improved metabolism of glucose. The action of PPARγ on muscle insulin sensitivity may be secondary to the lowering of circulating lipids on PPAR-gamma activation. Both GLUT-4 and PPARγ are regulators of glucose and lipid metabolism, allowing adaptation to the physiological environment. The results showed that the ethanolic extract of SXA in the dose of 100 μg/ml produced an upregulation of both GLUT-4 and PPARγ gene expression in L6 cell lines.

Author(s): Anitha Mary Mathews

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