Study of S-substituted triazinothiocarbamides in dioxane water mixture

In last four decades, S-triazine and thiocarbamide group containing drug create their own identity in the drug, pharmaceutical and medicinal sciences. The Viscometric Refractrometric, Interferometric measurements of recently synthesized drug have been carried out for solutions of 1-(4-hydroxy-6-methyl)-S-triazino-3-phenylthiocarbamide (L1) and 1-(4-hydroxy-6-methyl)-S-triazino-3-methylthiocarbamide (L2) at various concentrations. Hence, density and sound velocity of biologically important substituted triazinothiocarbamides were measured at 30°C in 60% dioxane-water mixture. The result obtained during this investigation directly through light on the dipole association of compound, intermolecular attraction between solute and solvent, dielectric constant of medium, polarizability and mutual compensation of dipoles, various acoustic/ thermodynamic parameters and useful for drug absorption, transmission, stability, activity and effect of these on drugs which is base of pharmacokinetics and pharmacodynamics of any drug. Taking all these things into consideration this research work was carried out

Author(s): D. T. Tayadea,A. M. Kshirsagarb and D. T. Tayadea

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