Abstract

Solubility enhancement of a poorly aqueous soluble drug ketoprofen using solid dispersion technique

Ketoprofen has low solubility in water and it is having dissolution problems. The objective of the present research is to enhance the aqueous solubility of the poorly water soluble drug (Ketoprofen) by formulation of solid dispersion systems with the use of Gelucire 44/14 and PVP K30 as a polymer in the formulation. The formulation of solid dispersion by solvent evaporation method is introduced to reduce the drug particle size and hence increase the dissolution rate. These dispersions were characterized with the help of DSC and X-ray diffraction studies. Dissolution of solid dispersions of ketoprofen in phosphate buffer (pH 7.4) was studied using USP dissolution test apparatus II. The results reveal that the solid dispersions of ketoprofen showed an improvement in the rate and extent of drug dissolution.


Author(s): Nagar Gauri, Luhadiya Aditi, Agrawal Shikhaa, Dubey P. K.

Abstract | PDF

Share This Article
Awards Nomination 17+ Million Readerbase
Google Scholar citation report
Citations : 4713

Der Pharmacia Sinica received 4713 citations as per Google Scholar report

Abstracted/Indexed in
  • Google Scholar
  • Genamics JournalSeek
  • China National Knowledge Infrastructure (CNKI)
  • Directory of Research Journal Indexing (DRJI)
  • Proquest Summons
  • MIAR
  • International Committee of Medical Journal Editors (ICMJE)
  • Serials Union Catalogue (SUNCAT)
  • Geneva Foundation for Medical Education and Research
  • Secret Search Engine Labs
  • CAS (Chemical Abstracting Services)
  • University of Barcelona

View More »

Flyer image