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Solubility enhancement of a poorly aqueous soluble drug ketoprofen using solid dispersion technique

Ketoprofen has low solubility in water and it is having dissolution problems. The objective of the present research is to enhance the aqueous solubility of the poorly water soluble drug (Ketoprofen) by formulation of solid dispersion systems with the use of Gelucire 44/14 and PVP K30 as a polymer in the formulation. The formulation of solid dispersion by solvent evaporation method is introduced to reduce the drug particle size and hence increase the dissolution rate. These dispersions were characterized with the help of DSC and X-ray diffraction studies. Dissolution of solid dispersions of ketoprofen in phosphate buffer (pH 7.4) was studied using USP dissolution test apparatus II. The results reveal that the solid dispersions of ketoprofen showed an improvement in the rate and extent of drug dissolution.

Author(s): Nagar Gauri, Luhadiya Aditi, Agrawal Shikhaa, Dubey P. K.

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