Solid state properties: Preparation and characterization

The field of solid state characterization is central to the pharmaceutical industry, as drug products are manufactured as solid materials. Selection of the optimum solid form is a critical aspect in the development of pharmaceuticals, due to their ability to exist in more than one form or crystal structure (polymorphism). These polymorphs show different physical properties which can affect their biopharmaceutical properties. The possible result of changing crystal forms during late-stage of drug development had gave a good reason for the well thought out and early characterization of polymorphism. A detail understanding of polymorph characteristics allows selection of the best form to market. The focus is on recent developments and combined description strategy for different types of polymorphs using spectroscopic, crystallographic, microscopic and thermal methods of analysis.

Author(s): Krishna R. Gupta, Sonali S. Askarkar, Rachana R. Joshi and Yamini F. Padole

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