A simple, precise and rapid stability-indicating HPLC method was developed for the simultaneous quantitative determination of Telmisartan, Amlodipine and Hydrochlorothiazide from their innovative Pharmaceutical combination drug product, with the presence of degradation products. The separation was achieved on simple gradient method. The detector wavelength was 260 nm. The total runtime was 35min. and RT of Hydrochlorothiazide, Amlodipine and Telmisartan are 4.4, 8.2 and 18.7 min. respectively. The described method was validated with respect to system suitability, specificity, linearity, precision and accuracy.