Safe alternative for fluoride in dentifrice. How theobromine was discovered?

Statement of the Problem: Caffeine (1,3,7- trimethyxanthine) and theobromine (3,7- dimethyxanthine) both are members of the xanthine family. Coffee and many soft drinks contain caffeine. Theobromine is the main ingredient in cacao and chocolate is made from. Over 35 years ago, simple experiment in which the diet fed to lactating dams had caffeine added. The mineral contents of the tooth from the pups which sucked the caffeine-containing dam’s milk were decreased. The experiments were started to determine if caffeine would affect either enamel or dentin or both.

Author(s): Tetsuo Nakamoto

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