Role of breast imaging to predict molecular subtype, histologic grade and hormone receptor status of breast cancer

The number of cancers diagnosed during pregnancy is on the
rise and breast cancer is the most common malignancy.
Presently, there are very limited resources and no clear
guidelines for managing this peculiar patient population both
worldwide as well as in India.
The objective of this study was to find out the incidence of
pregnancy associated breast cancer (PABC) in a tertiary care
referral center and to compare the epidemiological, diagnostic
and prognostic factors as well as maternal and fetal outcomes
with the most recent literature worldwide
Methods- We conducted a retrospective descriptive study of
women diagnosed with breast cancer in pregnancy and postpartum
period at Amrita Institute of Medical Sciences, Kochi
during the period of 10 years. We studied the diagnostic and
prognostic factors as well as maternal and fetal outcome in
patients diagnosed with breast cancer for the first time in
pregnancy.Results- Overall incidence of PABC was found to
be 0.6% (n=10). Mean age at the time of presentation was 31
years. Most patients had an advanced stage disease on diagnosis
(70%). Histopathology suggested 90% had Invasive ductal
carcinoma and 55.5% had a triple negative receptor status. 20%
of our patients had opted for a breast conservation surgery
(BCS) and 70% of our patients underwent Modified Radical
Mastectomy with neo-adjuvant or adjuvant chemotherapy. One
patient had an 1st trimester MTP in view of stage 4 disease.
77.7% underwent LSCS out of which 57.4% were elective and
MRM was done concurrently with LSCS in 50% of the elective
The mean birth weight was 2.2 kg. Intrauterine growth
retardation was seen in 22.2% neonates. 33.3% of the neonates
required NICU support and one baby expired on post-natal day
Tanay from Department of Surgical Oncology and
Pathology, Bhagwan Mahaveer Cancer Hospital and
Research Center

Author(s): Tanay shah

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