Rhematoid arthritis is a progressive chronic inflammatory condition affecting diathrodal joints leading to swelling deformity, pain and lack of function. Incidentally during the inflammatory phase there is elevated IL 6, IL1 B, TNF Alfa and acute phase proteins. Similarly chronic periodontitis is common infectious condition due to poor oral hygiene. Biological and chemical irritation causing inflammation, and inflammatory infiltrate leading to tissue swelling, degradation, bone destruction, mobility of teeth. In this lecture, there will be concise discussion of various factors and inflammatory products that emerge in RA and chronic periodontitis .A few modalities to suppress the inflammatory modulators will also be discussed.