Release characteristics of drugs from cross linked tamarind seed polysaccharide matrix tablets

The study was aimed isolate tamarind seed polysaccharide from tamarind kernel powder, crosslinking of isolated polysaccharide with epichlorohydrin and to assess the release behaviour of drugs, diclofenac sodium and ketoprofen from isolated tamarind seed polysaccharide and cross linked tamarind seed polysaccharide as release retardant. The presence of polysaccharide was confirmed by phytochemical analysis. The drugs and isolated polysaccharide was found to be compatible as confirmed by IR spectral studies. The TSP powder was evaluated for its micromeritic properties viz. Bulk density, tap density, angle of repose, Hausners’s ratio, Carr’s index and bulkiness and the results indicated good flow properties. The formulations were prepared using TSP powder and crosslinked TSP powder. The prepared granules were free flowing and the compressed tablets showed good friability and hardness. The drug content of all the prepared formulations was ranging from 96.5- 100.0%. The rate of drug release form formulations containing crosslinked TSP was slow when compared to the formulations containing TSP without crosslinking. The release data was incorporated into various mathematical models and the drug release mechanism of formulations was found to be Fickian, non Fickian diffusion and super case II transport. This study confirmed that the crosslinked TSP can be used as an effective release retardant and can be successfully used in commercial products.

Author(s): Bodempudi Sravani, R. Deveswaran, S. Bharath, B. V. Basavaraj and V. Madhavan

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