Pyoderma Gangrenosum is an autoimmune disease which is associated with number of other systemic diseases mainly ulcerative colitis, crohn’s disease, rheumatoid arthritis and few others. But the rare associations are PG with oral involvement and PG with liver abnormalities. Uniqueness of this case is that, it has both of these rare characteristics. A 20 year old patient presents with the diffuse involvement of skin ulceration along with the oral ulcers too. He was diagnosed on the basis of the ulcer’s biopsy report and all other associations were denied appropriately with the help of colonoscopy, endoscopy and Extractable Antigen Nuclear Profile. So, initially he was started on prednisone and he responded well but then he started to develop the Iatrogenic Cushing Syndrome so then his medication was changed to the cyclosporine. Later on, his Hepatitis-C, ELISA came to be positive, so then his medication for that was started too.